"The Pope has dishonoured our Prophet. He said our Prophet was a terrorist and he had used sword. Those who say such things whether they are in India or abroad should be punished," said Syeda Tasnim Hasan, a protestor in Jammu.
"His statements have hurt our sentiments. If such statements are repeated the followers of Islam across the world would launch an agitation against Christians," said Mohammed Farooq, a protestor in Varanasi.
In Kashmir, dozens of lawyers wearing black court robes marched Friday through the streets of the summer capital Srinagar, shouting, "Those who dare to target Islam and the Holy Prophet (PBUH) will be finished".
"We have heard about your extremism and hate for Arabs and Muslims. Now that you have dropped the mask from your face we see its ugliness and extremist nature," Syria's top Sunni Muslim religious authority, Sheik Ahmad Badereddine Hassoun.
The Pope's comments were a hot topic on a pro-Hamas radio show for children.
"What do you say about the man who said some bad words about Islam and the Prophet Mohammad?" the radio host asked a 8-year-old Hanin.
Hanin answered: "He is ugly and his words are ugly."